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May 20, 2023Liked by Etienne de la Boetie2

In this study there are three experiments:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789927/

The first one is this underpowered (small) study of living people, by blood test. A lot of imagination is needed to argue that it is reasonable to expect that a similar experiment involving 50,000 would yield similar results.

The second experiment is performed on four 3cc samples of tissue taken from testicles of deceased men with prostate cancer. I argue that a dead testicle is probably decaying and won't work normally to produce sperm, ibuprofen or not. This is bogus. To deduce "compensatory hypogonadism" using dead and decaying tissue from a deceased donor with cancer is a stretch, in my opinion: nothing it's getting compensated, those organs are decomposing.

And it's not even the whole testicle. Samples from testicles from dead men, exposed to toxic substances, in a well, then beaten up by lab machines many times. These inferences are impossible to make. Those testis have seen better days, no doubt.

The third experiment is even worse. It's about a human cell line from a adrenocortical carcinoma, which is related to the adrenal glands that exist on top of the kidneys. It has always been known that ibuprofen damages the kidneys and affects the endocrine system in general. That's how it works to reduce inflammation.

The truth is that anything can affect the reproductive system in humans. In the spring, the air is loaded with polen from the trees and flowers, it's like a drug, all animals receive that in their bodies as they breathe. The light from the sun also affects the reproductive system. And the absence of light.

In out synthetic world, all plastics seem to affect a little bit our system. And it is a safe assumption that all petroleum derived drugs affect the endocrine system and the reproductive system. (Aren't people crazy these days?)

Even worse, curcuma root, turmeric, has a long standing tradition as a plant extract meant to regulate hormones. It also reduces fertility and I can imagine that has been used as a eugenics drug for thousands of years. They are a ton of racists in India.

Any anti-inflammatory compound is used to correct the body, which wants to be in one state and we don't want it to be in that state, because we cannot rest and we have to work, etc. There are always invisible consequences.

And the tradition of those who want big muscles in their bodies is to follow nature: heavy exercise until it hurts, then rest. No drugs. Resting is the moment when the muscles grow. Rinse and repeat.

Bulls and buffaloes and gnus are very strong. They run a break things and fight, and rest, and rest some more, and then more rest, and then it's another day. No drugs, other than what the earth and the water and the air provide.

Cheating the system with drugs will have bad consequences. Perhaps this small study shows a glimpse of how those consequences are. Perhaps not.

Muscle men must be informed that too much ibuprofen and their daughters will probably be communists. That's the worst imaginable outcome.

DMSO alone probably has a better analgesic effect and it does not affect the endocrine system in this way. For people with chronic pain, of any age, we need real analgesics that help them and hurt them less than the current NSAIDs and acetaminophen. And the ideal of treating the root cause of a disease is fine, but if it is not possible, it is reasonable to have an alternative, which is helping the pain. But the alternative is now the primary care. That's the whole problem in a nutshell.

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