Ibuprofen Shrinks Testicles, lowers Testosterone, linked to infertility
*SEE COMMENTS* The commonly prescribed painkiller and anti-inflammatory, ibuprofen, has been linked to shrinking testicles, lowered testosterone levels and infertility issue in a shocking study.
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With plummeting testosterone levels and skyrocketing infertility levels, the revelation adds fuel to the fire, as fitness coaches and health gurus scramble to draw attention to the looming disaster.
In 2018, it was estimated that 15% of Americans take too much Ibuprofen — with the recommended daily limit being 3200mg per day. Additionally, Americans take an estimated 30 billion doses of painkillers similar to and including Ibuprofen which totals 16.5 million prescriptions.
Researchers from Denmark and France found in the paper Proceedings of the National Academy of Sciences that prolonged use of the commonly consumed painkiller could have some nasty side effects.
Net Doctor reported: “The small study, made up of just 31 male participants aged 18 to 35 years old, showed that taking ibuprofen increased the risk of compensated hypogonadism – a hormone imbalance whereby an individual has higher levels of luteinizing hormone (LH) than testosterone.
“For the research, participants were split into two groups. one group received 600mg or ibuprofen twice a day two weeks before and 30 days after an exercise session while the other acted as a control group. For the ibuprofen group, blood tests showed an 18% decrease in testosterone after 14 days, rising to a 23% decrease after 44 days.”
What is particularly alarming about the study is the participants were consuming around a third of what is considered a safe daily dose.
According to the study:
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role.
Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named “compensated hypogonadism,” a condition prevalent among elderly men and associated with reproductive and physical disorders.
In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line.
Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
Taking Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) before or after training can interfere with recovery.
Acute inflammation is a necessary part of recovery.
Excessive Ibuprofen consumption has been linked with stomach bleeding, heart attacks and death.
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In this study there are three experiments:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789927/
The first one is this underpowered (small) study of living people, by blood test. A lot of imagination is needed to argue that it is reasonable to expect that a similar experiment involving 50,000 would yield similar results.
The second experiment is performed on four 3cc samples of tissue taken from testicles of deceased men with prostate cancer. I argue that a dead testicle is probably decaying and won't work normally to produce sperm, ibuprofen or not. This is bogus. To deduce "compensatory hypogonadism" using dead and decaying tissue from a deceased donor with cancer is a stretch, in my opinion: nothing it's getting compensated, those organs are decomposing.
And it's not even the whole testicle. Samples from testicles from dead men, exposed to toxic substances, in a well, then beaten up by lab machines many times. These inferences are impossible to make. Those testis have seen better days, no doubt.
The third experiment is even worse. It's about a human cell line from a adrenocortical carcinoma, which is related to the adrenal glands that exist on top of the kidneys. It has always been known that ibuprofen damages the kidneys and affects the endocrine system in general. That's how it works to reduce inflammation.
The truth is that anything can affect the reproductive system in humans. In the spring, the air is loaded with polen from the trees and flowers, it's like a drug, all animals receive that in their bodies as they breathe. The light from the sun also affects the reproductive system. And the absence of light.
In out synthetic world, all plastics seem to affect a little bit our system. And it is a safe assumption that all petroleum derived drugs affect the endocrine system and the reproductive system. (Aren't people crazy these days?)
Even worse, curcuma root, turmeric, has a long standing tradition as a plant extract meant to regulate hormones. It also reduces fertility and I can imagine that has been used as a eugenics drug for thousands of years. They are a ton of racists in India.
Any anti-inflammatory compound is used to correct the body, which wants to be in one state and we don't want it to be in that state, because we cannot rest and we have to work, etc. There are always invisible consequences.
And the tradition of those who want big muscles in their bodies is to follow nature: heavy exercise until it hurts, then rest. No drugs. Resting is the moment when the muscles grow. Rinse and repeat.
Bulls and buffaloes and gnus are very strong. They run a break things and fight, and rest, and rest some more, and then more rest, and then it's another day. No drugs, other than what the earth and the water and the air provide.
Cheating the system with drugs will have bad consequences. Perhaps this small study shows a glimpse of how those consequences are. Perhaps not.
Muscle men must be informed that too much ibuprofen and their daughters will probably be communists. That's the worst imaginable outcome.
DMSO alone probably has a better analgesic effect and it does not affect the endocrine system in this way. For people with chronic pain, of any age, we need real analgesics that help them and hurt them less than the current NSAIDs and acetaminophen. And the ideal of treating the root cause of a disease is fine, but if it is not possible, it is reasonable to have an alternative, which is helping the pain. But the alternative is now the primary care. That's the whole problem in a nutshell.