How does acetyl-CoA supplementation affect cellular senescence
Acetyl-CoA supplementation significantly affects cellular senescence by mitigating the effects of fatty acid oxidation (FAO) inhibition. Research shows that adding acetyl-CoA can nearly completely rescue cells from senescence induced by FAO inhibition, primarily by replenishing cytosolic acetyl-CoA levels. This supplementation reduces markers of senescence, such as p53 and p21, and restores autophagy processes that are disrupted during FAO inhibition. Thus, acetyl-CoA plays a crucial role in regulating cellular senescence, suggesting its potential as a therapeutic strategy for age-related conditions[1][2].
Dr. Mercola changed his diet last year or so from low-carb to Energy Balance. He was heavily influenced by watching the numerous Jay Feldman-Mike Fave videos. He needs to take diet seriously as he has reduced kidney function, but he now eats a lot of watermelon throughout the day and raw egg yolks from his own, well-fed chickens.
Energy Balance is Ray Peat-inspired and cautions against too much fat--more than, say, 30 to 40%. Ray got most of his carbs from orange juice and reduced-fat milk, but Mercola seems to favor watermelon.
My personal concerns with low-carb/carnivore are with the typical, chronically elevated cortisol, the stress hormone, and some other elevated markers of stress. Also, elevated fasting blood sugar.
Still, as Dr. Paul Saladino (animal-based plus fruit) says, "If you're thriving, don't change a thing."
Acetyl-CoA supplements are designed to support energy metabolism and reduce fatigue. They often contain ingredients like calcium pyruvate, pantothenic acid (Vitamin B5), and other compounds that facilitate the production of Acetyl-CoA, which is crucial for the Krebs cycle and energy production in cells[1][3][5]. These supplements may benefit athletes and individuals experiencing fatigue, particularly as mitochondrial function declines with age[1]. However, it's advisable to consult a healthcare provider before starting any supplement regimen[2].
How does acetyl-CoA contribute to the production of ketone bodies
Acetyl-CoA is essential for the production of ketone bodies during ketogenesis, particularly when carbohydrate availability is low. It is generated from fatty acid β-oxidation and, when the citric acid cycle is overwhelmed (due to low oxaloacetate), excess acetyl-CoA is diverted to form ketone bodies like acetoacetate and beta-hydroxybutyrate. The initial step involves the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA, catalyzed by HMG-CoA synthase, leading to further reactions that produce ketone bodies[1][2][3]. These ketone bodies serve as an alternative energy source, especially for the brain during fasting or low-carbohydrate conditions[4].
How does acetyl-CoA supplementation affect cellular senescence
Acetyl-CoA supplementation significantly affects cellular senescence by mitigating the effects of fatty acid oxidation (FAO) inhibition. Research shows that adding acetyl-CoA can nearly completely rescue cells from senescence induced by FAO inhibition, primarily by replenishing cytosolic acetyl-CoA levels. This supplementation reduces markers of senescence, such as p53 and p21, and restores autophagy processes that are disrupted during FAO inhibition. Thus, acetyl-CoA plays a crucial role in regulating cellular senescence, suggesting its potential as a therapeutic strategy for age-related conditions[1][2].
Citations:
[1] Fatty acid oxidation regulates cellular senescence by modulating the ... https://pmc.ncbi.nlm.nih.gov/articles/PMC10761749/
[2] Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell ... https://pmc.ncbi.nlm.nih.gov/articles/PMC9385365/
[3] ApoE4 exacerbates the senescence of hippocampal neurons and spatial ... https://onlinelibrary.wiley.com/doi/10.1111/acel.13932
[4] Citrate metabolism controls the senescent microenvironment via ... https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00825-8
[5] Mitochondrial fatty acid oxidation drives senescence - Science https://www.science.org/doi/10.1126/sciadv.ado5887
[6] ATP‐citrate lyase regulates cellular senescence via an AMPK‐ and p53 ... https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.13139
Thanks for the value-add! I am currently reading: The Death of Death!
Dr. Mercola changed his diet last year or so from low-carb to Energy Balance. He was heavily influenced by watching the numerous Jay Feldman-Mike Fave videos. He needs to take diet seriously as he has reduced kidney function, but he now eats a lot of watermelon throughout the day and raw egg yolks from his own, well-fed chickens.
Energy Balance is Ray Peat-inspired and cautions against too much fat--more than, say, 30 to 40%. Ray got most of his carbs from orange juice and reduced-fat milk, but Mercola seems to favor watermelon.
My personal concerns with low-carb/carnivore are with the typical, chronically elevated cortisol, the stress hormone, and some other elevated markers of stress. Also, elevated fasting blood sugar.
Still, as Dr. Paul Saladino (animal-based plus fruit) says, "If you're thriving, don't change a thing."
Great value add!
You can trust the science, I’ll trust carnivore.
When it ends up with "here's the magic supplement," I'm out.
acetyl-CoA supplements
Acetyl-CoA supplements are designed to support energy metabolism and reduce fatigue. They often contain ingredients like calcium pyruvate, pantothenic acid (Vitamin B5), and other compounds that facilitate the production of Acetyl-CoA, which is crucial for the Krebs cycle and energy production in cells[1][3][5]. These supplements may benefit athletes and individuals experiencing fatigue, particularly as mitochondrial function declines with age[1]. However, it's advisable to consult a healthcare provider before starting any supplement regimen[2].
Citations:
[1] Acetyl CoA Support Formula Nutritional Supplement - Metabolics https://www.metabolics.com/products/acteyl-coa-support-formula-pot-of-60-capsules
[2] Acetylcholine Supplements: Benefits, Side Effects, and Types - Healthline https://www.healthline.com/nutrition/acetylcholine-supplement
[3] Coenzyme-A Technologies Pure Coenzyme A 700 mg 90 Caps - QFC https://www.qfc.com/p/coenzyme-a-technologies-pure-coenzyme-a-700-mg-90-caps/0069796306015
[4] Acetate supplementation produces antidepressant-like effect ... - PubMed https://pubmed.ncbi.nlm.nih.gov/33290927/
[5] Acetyl CoA Factors pack of 60 capsules - Epigenetics International https://epigenetics-international.com/product/acetyl-coa-factors-pack-of-60-capsules/
[6] Acetyl-Coenzyme A (sodium salt) - Cayman Chemical https://www.caymanchem.com/product/16160/acetyl-coenzyme-a-(sodium-salt)
How does acetyl-CoA contribute to the production of ketone bodies
Acetyl-CoA is essential for the production of ketone bodies during ketogenesis, particularly when carbohydrate availability is low. It is generated from fatty acid β-oxidation and, when the citric acid cycle is overwhelmed (due to low oxaloacetate), excess acetyl-CoA is diverted to form ketone bodies like acetoacetate and beta-hydroxybutyrate. The initial step involves the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA, catalyzed by HMG-CoA synthase, leading to further reactions that produce ketone bodies[1][2][3]. These ketone bodies serve as an alternative energy source, especially for the brain during fasting or low-carbohydrate conditions[4].
Citations:
[1] 17.3: Ketone Bodies - Biology LibreTexts https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02:_Unit_II-_Bioenergetics_and_Metabolism/17:_Fatty_Acid_Catabolism/17.03:_Ketone_Bodies
[2] Ketogenesis - Wikipedia https://en.wikipedia.org/wiki/Ketogenesis
[3] Ketone body metabolism and cardiovascular disease - PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC3625904/
[4] Ketone bodies - Wikipedia https://en.wikipedia.org/wiki/Acetone_body
[5] Ketone bodies: a review of physiology, pathophysiology and ... https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-7560(199911/12)15:6%3C412::AID-DMRR72%3E3.0.CO;2-8/full